tissue. This is no reason to demonize these drugs, the researchers firmly insist.
A particular percentage of the adult population has not just white adipose (or fatty) tissue, however likewise the brown kind. This brown adipose tissue helps to transform sugar and fat into heat.
People with brown adipose tissue are much better at regulating their body temperature level in the winter, and are less most likely to experience excess weight or diabetes.
A global group of scientists led by ETH Zurich has actually now found that the statin class of pharmaceuticals reduces the development of brown adipose tissue.
Statins are recommended as a method to reduce the danger of a heart attack given that they decrease cholesterol levels in the blood. They are among the most typically prescribed drugs worldwide.
The scientists have been investigating brown adipose tissue for several years.
They looked into the concern of how “bad” white fat cells, which form the layer of fat under our skin, end up being “excellent” brown fat cells.
Having actually conducted cell culture experiments, they learnt that the biochemical pathway responsible for producing cholesterol plays a main function in this change.
They also discovered that the crucial molecule regulating the change is the metabolite geranylgeranyl pyrophosphate.
Earlier research studies showed that the cholesterol biochemical pathway is likewise main to the functioning of statins; one of their results is to lower the production of geranylgeranyl pyrophosphate.
This is why the scientists needed to know whether statins likewise impact the development of brown fat. And certainly they do, as the scientists have now displayed in research studies on mice and people.
One thing the researchers did was research study positron emission tomography scans of 8,500 patients at the University Health Center Zurich.
This let them determine whether the individual had brown adipose tissue. It was also understood whether the clients were taking statins.
Examining the scans shows that 6 percent of those not taking the medication had brown adipose tissue, however this tissue type was present in only a little over 1 percent of those who were taking statins.
The scientists carried out a separate scientific research study of 16 individuals at the University Medical Facilities of Basel and Zurich to demonstrate that statins reduce the activity of brown fat.
Although the research study demonstrated that statins have an unfavorable impact, the team warns against talking them down.
However, statins likewise have another negative result: in high doses, they somewhat increase some individuals’s danger of establishing diabetes– as has actually been shown in other research studies.
However the group stresses that even if such a link were developed, that would be no factor to demonize statins.
Rather, it would end up being important to perform further research into the mechanisms behind this and discover which patients are impacted.
It might then be possible to take a personalized medication method and continue to suggest statins to the majority of people, while proposing alternative treatments for a small group of patients.
Written by Fabio Bergamin.
Source
https://knowridge.com/2018/12/cholesterol-lowering-drugs-could-reduce-brown-fat-linked-to-weight-loss/
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